The Lamborghini Islero also called Islero 400 GT is a grand touring automobile produced by the Italian manufacturer Lamborghini.

Presented in March 1968 at the Geneva International Motor Show, it succeeded the Lamborgini 400 GT 2+2.

The name Islero is attributed in reference to the bull that killed the famous matador Manolete in the arena in 1947.

After 125 copies produced between March 1968 and February 1969, a slightly modified version called S appears, it will be produced in 100 copies until 1969 and will be replaced in 1970 by the Lamborghini Jarama.

The mechanics of the Lamborghini Islero is that of its predecessor whose anti-roll bars and brake discs have been oversized. It is equipped with the V12 engine open at 60°, with a displacement of 3,929 cm3 developing 320 hp exceeding 250 km/h.